Philip J. Griebel, DVM, Vaccine and Infectious Disease Organization,
At the 2009 AABP, Griebel said functional genomic analyses suggest antiviral responses were linked to an increased capacity to respond to Gram-negative bacterial respiratory infections through increased expression of TLR4 and CD14.
These analyses provide evidence for a novel mechanism by which stress may enhance the risk of fatal BRD. In addition, modulation of TLR expression during viral infection may be of relevance for both Gram-negative and Gram-positive bacterial infections. These molecular analyses should facilitate the identification of appropriate therapeutic targets for the prevention or treatment of stress-enhanced BRD infections.