This week, November 18 to 24, is Antibiotic Awareness Week in the United States, Hong Kong, Canada and Australia. Thailand, Europe and Mexico among others observe Antibiotic Awareness Day on November 18. Over the past few days, we have run a series of articles from the multi-disciplinary conference on antibiotic resistance hosted by the National Institute for Animal Agriculture last week in Kansas City. In keeping with the theme, the medical journal The Lancet this week published an editorial calling for a coordinated, global effort to combat antibiotic resistance.
To address the issue, The Lancet appointed an international expert commission, which operates under the theme of “Antibiotic resistance—the need for global solutions.” The goal of the Commission is to explore “why antibiotic resistance has become such a problem worldwide, and, most importantly, proposes solutions to avert the impending crisis.” The Lancet recruited experts in the various topics and asked them to write pieces focusing on how we got to this point and potential solutions to the problem. The individual contributions were peer-reviewed, revised, and assembled into a single document.
Antibiotics paved the way for unprecedented medical and societal developments, and are today indispensible in all health systems, the commission notes. “Achievements in modern medicine, such as major surgery, organ transplantation, treatment of preterm babies, and cancer chemotherapy, which we today take for granted, would not be possible without access to effective treatment for bacterial infections. Within just a few years, we might be faced with dire setbacks, medically, socially, and economically, unless real and unprecedented global coordinated actions are immediately taken.”
The group says bacterial resistance has resulted from use of antibiotics "prescribed pointlessly for viral infections, added to animal feed to boost growth of livestock, and handed out like cough sweets in the community."
The report notes that non-prescription antibiotic use is common in many countries, accounting for 19 to 100 percent of antibiotic use outside northern Europe and North America. It also notes that when prescriptions are needed to obtain antibiotics, physicians might not adequately screen for appropriate use.
The authors also say antibiotic use in veterinary medicine and for growth promotion and disease prevention in agriculture, aquaculture, and horticulture is also a major contributing factor. “Although precise estimates are scarce, of the crudely estimated 100 000—200 000 tonnes of antibiotics manufactured every year, most goes to the agricultural, horticultural, and veterinary sectors. Although the transfer of antibiotic resistance plasmids from treated animals to human beings has been long suspected, findings from recent studies using whole-genome sequencing have confirmed animal-to-human transfers of resistance genes.”