For almost 40 years, digital dermatitis has plagued cattle throughout the world. Also called heel warts, these painful hoof lesions limit the amount of time cows can stand and feed, which can hinder animal welfare and food production. The disease can be found on almost every beef and dairy farm in North America, so it has a significant economic impact on those industries in the United States.
Hoof baths involve soaking infected hooves in solutions of copper sulfate or formaldehyde, which can be environmentally problematic or hazardous to the health of dairy workers, so alternative treatments like feed supplements and botanically derived baths are welcome.
Hoof baths involve soaking infected hooves in solutions of copper sulfate or formaldehyde, which can be environmentally problematic or hazardous to the health of dairy workers, so alternative treatments like feed supplements and botanically derived baths are welcome. Photo: Nigel Cook Fortunately, researchers at the UW-Madison School of Veterinary Medicine are helping to find new ways to address the disease. Some of this work has led to the development of safer, more effective treatments. But the road to these innovative approaches began with the creation of an effective testing method.
"For digital dermatitis, we developed an experimental infection model to reproduce and treat acute digital dermatitis lesions in cattle in a standardized way and in a controlled environment," says Dörte Döpfer, assistant professor of food animal medicine and an expert in veterinary epidemiology. This involved isolating a very small population of cattle in a laboratory setting free from other factors that can affect the natural course of the disease.
According to Döpfer, the experimental model helps improve animal welfare. Many treatment and preventive measures hit the market before being properly tested, which can be detrimental to millions of cattle. The infection model allows her research team to pre-screen products on a small-scale population before they are used in the field.
"In addition, the impact on the test cows is minimal," says Döpfer. "As part of any study, the induced acute lesions are treated with antibiotics immediately. The pain is gone within a day, and the lesions do not become chronic. The cattle lead a perfectly healthy life afterwards."
The experimental model has been used successfully in university-industry partnerships aimed at developing better ways to prevent and treat digital dermatitis. Zinpro Corporation has been collaborating with Döpfer on clinical trials since 2010. By analyzing data from those trials, she and Arturo Gomez Rivas, a research assistant at the School of Veterinary Medicine, helped assess the effectiveness of treatments that prevent digital dermatitis in pre-calving heifers.